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Susan Weiss obtained her Ph.D. in Microbiology from Harvard University working on paramyxoviruses and did postdoctoral training in retroviruses at University of California, San Francisco with J. Michael Bishop and Harold Varmus. She moved to the Perelman School of Medicine at the University of Pennsylvania in 1980, where she established her research program in coronaviruses and where she is currently Professor and Vice Chair, Department of Microbiology and Co-director of the Penn Center for Research on Coronaviruses and Other Emerging Diseases. She is the past Associate Dean for Biomedical Postdoctoral Programs. She has worked on many aspects of coronavirus replication and pathogenesis over the last 40 years, making contributions to understanding the basic biology, as well as organ tropism and virulence. She has worked with murine coronavirus (MHV), MERS-CoV and, most recently, SARS-CoV-2. Her work for the last 10 years has focused on coronavirus interaction with the host innate immune response and viral innate antagonists of double-stranded RNA induced antiviral pathways. Her other research interests include activation and antagonism of the antiviral oligoadenylate-ribonuclease L (OAS-RNase L) pathway, flavivirus- primarily Zika- virus-host interactions and pathogenic effects of host endogenous dsRNA.